Motif Accessibility Deviation Scores across Single Cells

Enrichment; the route from accessibility to the factors likely reading an enhancer.

Questions this Concept answers

Why is a background or expected accessibility used when computing motif deviation scores, rather than raw peak counts alone?

jeremy Text

chromVAR • chromVAR

chromVAR measures, for each motif or annotation, how far a single cell's accessibility departs from the accessibility expected across all cells. Because sparse single-cell ATAC data are dominated by …