Narrowing the ABCC9 Locus with African-Ancestry Pulse Pressure Data
The paper's most easily misread step. No African-ancestry voices were recorded; the borrowed data is UK Biobank pulse pressure, N = 9,482, used purely for shorter LD blocks. In Europeans the higher-pitch alleles sit at 38-42% in a single LD class; in the African-ancestry sample they sit at 5-29% across several classes, which splits the set down to four candidates: rs10841900-A, rs11046213-T, rs861202-G, rs1643235-C. Teach the borrowing and its limits together.
Questions this Concept answers
- Why do shorter linkage disequilibrium blocks help narrow a credible set of variants?
This Concept is waiting for its first lesson!
The paper's most easily misread step. No African-ancestry voices were recorded; the borrowed data is UK Biobank pulse pressure, N = 9,482, used purely for shorter LD blocks. In Europeans the higher-pitch alleles sit at 38-42% in a single LD class; in the African-ancestry sample they sit at 5-29% across several classes, which splits the set down to four candidates: rs10841900-A, rs11046213-T, rs861202-G, rs1643235-C. Teach the borrowing and its limits together.
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