Next-Generation Sequencing

How massively parallel DNA sequencing technologies read millions of fragments simultaneously.

Questions this Concept answers

Why do NGS reads need to be aligned to a reference genome before most downstream analyses?

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Illumina Sequencing by Synthesis in Next-Generation DNA Sequencing

Next-generation sequencing (NGS) is a massively parallel DNA/RNA sequencing paradigm, in contrast to single-strand-at-a-time Sanger sequencing, based on the principle that a long DNA/RNA molecule can…