Nucleosomes and the Accessibility of DNA to Transcription Factors

The physical basis of ATAC-seq and DNase-seq signals.

Questions this Concept answers

Why does nucleosome occupancy make a genomic region inaccessible to most transcription factors?

jeremy Video

Mapping Nucleosome Positions Using DNase-Seq in Chromatin Biology

This concept covers a statistical approach to inferring nucleosome positions from DNase digestion signal, based on the principle that nuclease cutting patterns around a nucleosome-wrapped DNA segment…