Acne vulgaris is a multifactorial dermatologic condition in which androgen-driven increases in sebum production during puberty lead to comedone formation from accumulated lipid and keratin within the follicular unit, followed by overgrowth of Propionibacterium acnes, bacterial conversion of sebum to fatty acids, and a resulting inflammatory response. This pathogenesis produces a spectrum of lesion morphologies distinguished by whether the overlying epidermis remains intact, and the condition is differentiated clinically from other follicular and facial inflammatory disorders with overlapping presentations.
Acne vulgaris is a multifactorial dermatologic condition in which androgen-driven increases in sebum production during puberty lead to comedone formation from accumulated lipid and keratin within the…