Peak Calling and Signal Normalization for Chromatin Sequencing Data

Turns reads into the intervals that annotation overlaps use; parameters change what a 'peak' is.

Questions this Concept answers

Why is it accurate to say 'a peak is a decision, not an observation'?

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Peak Calling with MACS2 in ChIP-seq Data Analysis

Peak calling in ChIP-seq analysis is the computational problem of identifying genomic regions where a protein of interest (e.g., a transcription factor) is significantly enriched for sequencing reads…