Peptide Synthesis Resin Selection
The resin choice sets both the mechanical behaviour (polystyrene versus PEG or PEG-polystyrene hybrids, swelling in DMF/DCM) and the C-terminal functionality delivered on cleavage, since the linker determines whether you obtain an acid, an amide, or a protected fragment. Highly acid-labile linkers such as 2-chlorotrityl release fully side-chain-protected fragments for convergent work.
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The resin choice sets both the mechanical behaviour (polystyrene versus PEG or PEG-polystyrene hybrids, swelling in DMF/DCM) and the C-terminal functionality delivered on cleavage, since the linker determines whether you obtain an acid, an amide, or a protected fragment. Highly acid-labile linkers such as 2-chlorotrityl release fully side-chain-protected fragments for convergent work.
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