Pioneer Transcription Factors and Opening Closed Chromatin

Links TF biology to accessibility assays and to cell-type identity.

Questions this Concept answers

Why are pioneer factors considered central to establishing cell-type identity?

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How Pioneer Transcription Factors Open Chromatin to Activate Genes

Pioneer transcription factors are a distinct class of DNA-binding regulatory proteins that, unlike canonical transcription factors requiring already-accessible DNA, can recognize and bind their targe…