Browse Teach Curate

Polygenic Architecture of Complex Traits and Missing Heritability

Calibrates expectations for effect sizes and explains why one locus is one small piece. Needed to interpret any odds ratio near 1.1.

Questions this Concept answers

Why does the heritability estimated from twin studies for a complex trait typically exceed the heritability explained by genome-wide significant variants alone?

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Epistasis and Missing Heritability in GWAS

Standard genetic association models are additive, assuming each additional copy of a reference allele contributes an independent, constant effect on phenotype; epistasis violates this assumption, des…