Polygenic Risk Scores from GWAS Effect Sizes

Enrichment: a common use of GWAS output that students ask about, but off the mechanism spine.

Questions this Concept answers

Why can a polygenic risk score predict risk without identifying any causal mechanism?

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How Polygenic Risk Scores Are Calculated in Genomics

A polygenic risk score quantifies an individual's genetic predisposition to a complex (polygenic) disease by aggregating the small, additive effects of many genetic variants across the genome, in con…