Porphyria Cutanea Tarda in Dermatology
Porphyria cutanea tarda is a metabolic disorder within dermatology caused by an inherited or acquired deficiency of uroporphyrinogen decarboxylase, an enzyme in the heme biosynthesis pathway, leading to accumulation of porphyrin intermediates that produce characteristic cutaneous manifestations. As a member of the broader porphyria disease family, it is defined by disruption of a specific step in heme synthesis, with disease expression modulated by environmental and pharmacologic triggers acting on a predisposed metabolic pathway.
Porphyria Cutanea Tarda in Dermatology
Porphyria cutanea tarda is a metabolic disorder within dermatology caused by an inherited or acquired deficiency of uroporphyrinogen decarboxylase, an enzyme in the heme biosynthesis pathway, leading…