Reading a Hi-C Contact Map: Compartments TADs and Loops

Apply-level interpretation skill separate from the assay.

Questions this Concept answers

Why do compartments appear as a checkerboard pattern rather than as squares along the diagonal?

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Hi-C (genomic analysis technique)

Hi-C measures how often any two genomic loci are physically near each other in the nucleus by crosslinking, digesting, ligating and sequencing chimeric DNA fragments, and the result is summarised as …