Reading the Credible Set at the ABCC9 Voice Pitch Locus
The worked instance. The lead marker rs11046212-T (beta = 0.11 SD per allele, P = 2.6e-18, +2.1 Hz per allele, frequency 47.7% in Iceland) resolves to a credible set of 15 — 14 SNPs plus one indel. Students should see a real credible set and count it, so 'one hit' stops meaning 'one culprit'.
Questions this Concept answers
- Why does a single strongly associated marker fail to identify the causal variant at a locus?
This Concept is waiting for its first lesson!
The worked instance. The lead marker rs11046212-T (beta = 0.11 SD per allele, P = 2.6e-18, +2.1 Hz per allele, frequency 47.7% in Iceland) resolves to a credible set of 15 — 14 SNPs plus one indel. Students should see a real credible set and count it, so 'one hit' stops meaning 'one culprit'.
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