Single-Cell eQTLs and Cell-State-Dependent Genetic Effects

Enrichment; the newest layer resolving the bulk-eQTL blindness.

Questions this Concept answers

Why can a genetic effect on expression be entirely missed in a bulk eQTL study but detected in a single-cell eQTL study?

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Single-Cell eQTL Analysis of Dynamic T Cell State-Specific Gene Regulation in Autoimmune Disease

Expression quantitative trait loci (eQTLs) are genetic variants that alter the expression level of a gene, and disease-associated risk alleles from genome-wide association studies (GWAS) are enriched…