Single-Cell Multiome: Joint RNA and ATAC from the Same Nucleus

Idea sketch 4 entry point; the data type that lets peak-to-gene links be inferred in one cell type.

Questions this Concept answers

Why does joint profiling of RNA and ATAC from one nucleus make peak-to-gene linking more reliable than combining separate RNA and ATAC datasets?

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Single-Cell Multiome Sequencing: Linking Open Chromatin and Gene Expression in Genomics

Single-cell multiome sequencing is a genomics method that jointly profiles gene expression (single-cell RNA-seq) and chromatin accessibility (single-cell ATAC-seq, "assay for transposase-accessible c…