Solid-Phase Peptide Synthesis
Merrifield's method anchors the growing chain's C-terminus to an insoluble polymer bead so excess soluble reagents drive each step to completion and are removed by filtration and washing rather than by isolation of intermediates. Chain assembly runs C-to-N, the opposite direction from ribosomal synthesis.
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Merrifield's method anchors the growing chain's C-terminus to an insoluble polymer bead so excess soluble reagents drive each step to completion and are removed by filtration and washing rather than by isolation of intermediates. Chain assembly runs C-to-N, the opposite direction from ribosomal synthesis.
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