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Stable Coordinates as the Design Constraint on a Reference Pangenome Graph

Why forbidding a sequence graph from collapsing two regions of the same genome onto one segment is what makes orthology, variation, and reference-anchored coordinates definable in a multi-genome reference.

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The design and construction of reference pangenome graphs

Heng Li, Xiaowen Feng and Chong Chu (Dana-Farber Cancer Institute and Harvard Medical School), arXiv 2003.06079v1, q-bio.GN, 13 March 2020, twelve pages, labelled METHOD, no journal reference. Primar…