Stratified LD Score Regression: Partitioning Heritability across Annotations and Cell Types

The genome-wide answer to 'which cell type' before any single-cell data.

Questions this Concept answers

Why can S-LDSC identify a trait-relevant cell type before any single-cell or locus-specific data is examined?

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Estimating SNP Heritability with LD Score Regression in Statistical Genetics

LD score regression is a statistical genetics method for estimating SNP heritability (and related quantities) from GWAS summary statistics alone, addressing two core complications: linkage disequilib…