Super-Enhancers and Cell Identity Genes

Enrichment; a useful heuristic but a contested concept.

Questions this Concept answers

Why do disease-associated variants cluster within super-enhancers more than expected by chance?

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Regulatory sequence

A super-enhancer is a cluster of enhancers packed within a short stretch of DNA and occupied at unusually high density by transcription factors, cofactors such as Mediator, and the active mark H3K27a…