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The Association Effect Size β as Change per Copy of an Allele

β is the slope of that regression, and by convention it is reported after the trait is standardised, so it lands in SD units. The seed paper's β = 0.11 SD per allele for rs11046212-T is the number the rest of the path argues about, so it needs a node of its own rather than a mention.

Questions this Concept answers

Why is \( \beta \) usually reported in standard deviation units rather than in the trait's measured units?

jeremy Text

GWAS Meta-analysis

In a genome-wide association study, each variant is tested by fitting a line between phenotype and genotype, where the genotype is coded as the number of copies of the alternate allele a person carri…