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The GWAS Per-Variant Regression Test and Effect Size

The actual statistic. Separating it from the overview lets apply-level questions compute and interpret a beta and its standard error.

Questions this Concept answers

Why is the effect size (beta) from a GWAS regression interpreted per copy of the effect allele?

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GWAS

A statistics chapter on how a genome-wide association study actually tests each variant. It sets up one regression per SNP with genotype coded 0, 1 or 2 copies of the effect allele under an additive …