Tissue-Specific eQTLs and the GTEx Resource

The practical lookup resource and its cell-type blindness.

Questions this Concept answers

Why can the same variant show a strong eQTL effect in one GTEx tissue but no effect in another?

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Context-Dependence of eQTL Effects Across Tissues, Ancestry, and Cell Type in GTEx

Expression quantitative trait loci (eQTLs) are genetic variants statistically associated with variation in gene expression, and their effects are highly context-dependent rather than fixed: the prese…