Topologically Associating Domains and CTCF Boundaries

Constrains which genes an enhancer can reach; boundary disruption is its own disease mechanism.

Questions this Concept answers

Why do enhancers rarely activate a promoter located in a neighboring topologically associating domain (TAD)?

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Topologically Associated Domains (TADs) and A/B Compartments in Chromatin Biology

Topologically associated domains (TADs) are sub-chromosomal units of three-dimensional genome organization, defined as contiguous chromosomal segments within which physical chromatin interactions occ…