Toxic Alcohol Poisoning: Ethanol, Methanol, and Ethylene Glycol in Toxicology
This concept covers the pharmacology and toxicology of clinically significant alcohols—ethanol, methanol, and ethylene glycol—within the field of toxicology. It addresses the kinetics of alcohol absorption and metabolism (zero-order kinetics, alcohol dehydrogenase and the microsomal ethanol-oxidizing system), the mechanism by which methanol and ethylene glycol are converted into toxic metabolites causing acidosis and organ damage, and the pharmacologic principle of competitive inhibition of alcohol dehydrogenase (via ethanol or fomepizole) as a treatment strategy to prevent toxic metabolite formation.
Toxic Alcohol Poisoning: Ethanol, Methanol, and Ethylene Glycol in Toxicology
This concept covers the pharmacology and toxicology of clinically significant alcohols—ethanol, methanol, and ethylene glycol—within the field of toxicology. It addresses the kinetics of alcohol abso…