Tracing a GWAS Variant to the Enhancer Gene and Cell Type It Breaks

The outcome node named by the curation. Every required chain ends here.

Questions this Concept answers

Why is naming a cell type a necessary part of a complete variant-to-function trace, rather than stopping once a target gene is identified?

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Understanding Complex Traits and Disease with Single-Cell Epigenomics

Single-cell epigenomics is the study of chromatin state, DNA methylation, and 3D genome conformation at the resolution of individual cells, used to map cell-type-specific transcriptional regulatory e…