Trans-Ancestry Fine-Mapping Using Differing LD Structures

Enrichment; a powerful technique but not required for the spine.

Questions this Concept answers

Why does combining ancestries with differing LD patterns shrink a credible set?

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Bayesian Fine-Mapping of Causal Variants in GWAS Loci

Fine-mapping is a statistical genetics technique addressing a core limitation of genome-wide association studies (GWAS): GWAS marginal regression detects statistical association between a variant and…