Transcriptome-Wide Association and Mendelian Randomization for Gene-Level Causality

Gene-level rather than variant-level evidence; enrichment-adjacent but widely reported.

Questions this Concept answers

Why does Mendelian randomization use genetic variants as instruments for a gene's expression on disease?

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Probabilistic Mendelian Randomization for Integrating GWAS and eQTL Data in Statistical Genetics

Transcriptome-wide association study (TWAS) methods integrate genome-wide association study (GWAS) and expression quantitative trait locus (eQTL) data by building a genetic predictor of gene expressi…