Uncompetitive Inhibition
The inhibitor binds only the ES complex, lowering apparent Vmax and apparent Km by the same factor (1 + [I]/Ki') so kcat/Km is unchanged; raising substrate makes it worse, and reciprocal plots are parallel.
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The inhibitor binds only the ES complex, lowering apparent Vmax and apparent Km by the same factor (1 + [I]/Ki') so kcat/Km is unchanged; raising substrate makes it worse, and reciprocal plots are parallel.
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