Weighing Lines of Evidence for a Causal Gene at a GWAS Locus

Evaluate-level synthesis; explicit about what each line of evidence can and cannot establish.

Questions this Concept answers

Why is it important to consider what each individual line of evidence can and cannot establish, rather than treating all supporting evidence as equally strong?

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GWAS-to-Drug-Target Pipeline for Causal Gene Prioritization

This pipeline is a multi-stage statistical genetics framework for converting genome-wide association study (GWAS) signals into causally validated drug targets by sequentially eliminating false positi…