Why a Deleteriousness Score Is Not a Phenotypic Effect Size
The path shows a high-constraint, high-CADD gene whose associated allele moves pitch by β = 0.11 SD, about 2.1 Hz. Holding those two together is the discipline this node installs: predicted damage and measured effect answer different questions and can disagree freely.
Questions this Concept answers
- Why can a gene look heavily constrained while the allele associated with it moves a trait only slightly?
This Concept is waiting for its first lesson!
The path shows a high-constraint, high-CADD gene whose associated allele moves pitch by β = 0.11 SD, about 2.1 Hz. Holding those two together is the discipline this node installs: predicted damage and measured effect answer different questions and can disagree freely.
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