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Why LD Block Length Reflects Population History

This is the population-genetics fact that makes trans-ancestry fine-mapping work at all. In the seed paper the European sample's higher-pitch alleles sit in a single LD class while the African-ancestry sample spreads them across several, which is exactly what shortens the candidate list.

Questions this Concept answers

Why do shorter linkage disequilibrium blocks help narrow a list of candidate causal variants?

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PDF 23 Linkage, recombination, and LD. - Stanford University

This chapter of Pritchard's An Owner's Guide to the Human Genome explains how linkage and recombination together shape haplotype structure. It defines D, D' and r-squared, derives the per-generation …