Why Many GWAS Loci Have No Matching eQTL

Evaluate-level node; the absence of an eQTL is not absence of a regulatory mechanism.

Questions this Concept answers

Why does the absence of an eQTL at a GWAS locus not mean the variant is non-regulatory?

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Colocalization of GWAS and eQTL Loci in Statistical Genetics

Colocalization is a statistical framework for determining whether the same causal variant underlies both a GWAS association and an expression quantitative trait locus (eQTL), addressing the ambiguity…