Winner's Curse and Replication of GWAS Associations

Guards against over-reading a discovery effect size when planning functional follow-up.

Questions this Concept answers

Why does the act of selecting a variant because it crossed a significance threshold bias its estimated effect size upward?

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Winner's Curse Bias Correction in GWAS Effect Size Estimation

Winner's curse is the statistical phenomenon in which effect-size estimates from ordinary least squares (OLS) regression—though unbiased unconditionally—become systematically inflated once estimates …