Worked Locus: FTO Intronic Variants Act on IRX3 and IRX5 in Adipocyte Progenitors

The canonical end-to-end example; every node in the path appears in it.

Questions this Concept answers

Why did early studies assume the FTO intronic variants acted on the FTO gene itself, before the IRX3/IRX5 mechanism was established?

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FTO gene - Wikipedia

FTO is the first obesity gene found by GWAS, and its page doubles as the canonical cautionary tale about nearest-gene reasoning. The associated variants sit in the first intron of FTO, yet the causal…